Reaction Details Report a problem with these data
Target
Beta-glucuronidase
Ligand
BDBM222211
Substrate
n/a
Meas. Tech.
β-Glucuronidase Assay
IC50
7.640e+4± 1.50e+3 nM
Citation
 Taha, M; Baharudin, MS; Ismail, NH; Selvaraj, M; Salar, U; Alkadi, KA; Khan, KM Synthesis and in silico studies of novel sulfonamides having oxadiazole ring: As ß-glucuronidase inhibitors. Bioorg Chem 71:86-96 (2017) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:
Protein
Mol. Mass.:
74736.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
  
Inhibitor
Name:
BDBM222211
Synonyms:
4-Methoxy-N'-(4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzoyl)benzenesulfonohydrazide (20)
Type:
Small organic molecule
Emp. Form.:
C23H20N4O6S
Mol. Mass.:
480.493
SMILES:
COc1ccc(cc1)S(=O)(=O)NNC(=O)c1ccc(cc1)-c1nnc(o1)-c1ccccc1OC
Structure:
Search PDB for entries with ligand similarity: