Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM222260
Substrate
n/a
Meas. Tech.
Alkaline Phosphatase Assay
pH
9.8±n/a
Temperature
310.15±n/a K
IC50
9.9e+2± 5e+1 nM
Comments
extracted
Citation
 Ejaz, SA; Saeed, A; Siddique, MN; Nisa, ZU; Khan, S; Lecka, J; Sévigny, J; Iqbal, J Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors. Bioorg Chem 70:229-236 (2017) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN
Type:
Protein
Mol. Mass.:
57094.82
Organism:
Bos taurus (Cattle)
Description:
P19111
Residue:
533
Sequence:
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLGDGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLCGVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDASVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQDHTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKANELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYALGGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHIMAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
  
Inhibitor
Name:
BDBM222260
Synonyms:
(Z)-4-(2-((E)-4-(3-methoxyphenyl)-1-morpholino-2-oxobut-3-enylidene)hydrazinyl) benzenesulfonamide (4c)
Type:
Small organic molecule
Emp. Form.:
C21H24N4O5S
Mol. Mass.:
444.504
SMILES:
COc1cccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)c1
Structure:
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