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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM222263
Substrate
n/a
Meas. Tech.
Alkaline Phosphatase Assay
pH
9.8±n/a
Temperature
310.15±n/a K
IC50
2.57e+3± 9.3e+2 nM
Comments
extracted
Citation
 Ejaz, SA; Saeed, A; Siddique, MN; Nisa, ZU; Khan, S; Lecka, J; Sévigny, J; Iqbal, J Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors. Bioorg Chem 70:229-236 (2017) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN
Type:
Protein
Mol. Mass.:
57094.82
Organism:
Bos taurus (Cattle)
Description:
P19111
Residue:
533
Sequence:
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLGDGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLCGVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDASVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQDHTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKANELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYALGGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHIMAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
  
Inhibitor
Name:
BDBM222263
Synonyms:
(Z)-4-(2-((E)-1-morpholino-2-oxo-4-(3,4,5-Trimethoxyphenyl)but-3-enylidene) hydrazinyl)benzenesulfonamide (4f)
Type:
Small organic molecule
Emp. Form.:
C23H28N4O7S
Mol. Mass.:
504.556
SMILES:
COc1cc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc(OC)c1OC
Structure:
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