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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM6115
Substrate
cdc2 substrate peptide
Meas. Tech.
Kinase inhibition Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
2.0±n/a nM
Citation
 Boschelli, DH; Wang, DY; Ye, F; Yamashita, A; Zhang, N; Powell, D; Weber, J; Boschelli, F Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles. Bioorg Med Chem Lett 12:2011-4 (2002) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM6115
Synonyms:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-{5-[(4-hydroxypiperidin-1-yl)methyl]thiophen-2-yl}quinoline-3-carbonitrile | 7-thienyl-3-quinolinecarbonitrile 17
Type:
Small organic molecule
Emp. Form.:
C27H24Cl2N4O2S
Mol. Mass.:
539.476
SMILES:
COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCC(O)CC3)s2)C#N)c(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
cdc2 substrate peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
100 uM ATP as co-substrate
Residue:
3
Sequence:
NA