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Target
DNA polymerase catalytic subunit
Ligand
BDBM222901
Substrate
n/a
Meas. Tech.
HCMV Polymerase LANCE TR-FRET Assay
pH
7.5±n/a
IC50
71±n/a nM
Comments
extracted
Citation
 Fader, L; Lepage, O; Bailey, M; Beaulieu, PL; Bilodeau, F; Carson, RJ; Giroux, A; Godbout, C; Moreau, B; Naud, J; Parisien, M; Poirier, M; Poirier, M; Surprenant, S; Thibeault, C Cytomegalovirus inhibitor compounds US Patent  US9315499 Publication Date 4/19/2016 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54
Type:
Protein
Mol. Mass.:
137111.39
Organism:
Human cytomegalovirus (HCMV strain AD169)
Description:
P08546
Residue:
1242
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
  
Inhibitor
Name:
BDBM222901
Synonyms:
US9315499, 3027
Type:
Small organic molecule
Emp. Form.:
C27H26ClN7O3
Mol. Mass.:
531.993
SMILES:
CC1(C)CN(C1)C(=O)Cn1c2nccc(-c3cnc(N)nc3)c2cc(C(=O)NCc2ccc(Cl)cc2)c1=O
Structure:
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