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Target
DNA polymerase catalytic subunit
Ligand
BDBM222906
Substrate
n/a
Meas. Tech.
HCMV Polymerase LANCE TR-FRET Assay
pH
7.5±n/a
IC50
30±n/a nM
Comments
extracted
Citation
 Fader, L; Lepage, O; Bailey, M; Beaulieu, PL; Bilodeau, F; Carson, RJ; Giroux, A; Godbout, C; Moreau, B; Naud, J; Parisien, M; Poirier, M; Poirier, M; Surprenant, S; Thibeault, C Cytomegalovirus inhibitor compounds US Patent  US9315499 Publication Date 4/19/2016 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54
Type:
Protein
Mol. Mass.:
137111.39
Organism:
Human cytomegalovirus (HCMV strain AD169)
Description:
P08546
Residue:
1242
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
  
Inhibitor
Name:
BDBM222906
Synonyms:
US9315499, 4012
Type:
Small organic molecule
Emp. Form.:
C24H23ClN8O3
Mol. Mass.:
506.944
SMILES:
CC1(C)CN(C1)C(=O)Cn1c2ncc(cc2cc(C(=O)NCc2ccc(Cl)cc2)c1=O)-c1nn[nH]n1
Structure:
Search PDB for entries with ligand similarity: