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Target
Protein arginine N-methyltransferase 6
Ligand
BDBM223137
Substrate
n/a
Meas. Tech.
In Vitro Enzymatic Assay
Temperature
298.15±n/a K
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
 Ji, S; Ma, S; Wang, WJ; Huang, SZ; Wang, TQ; Xiang, R; Hu, YG; Chen, Q; Li, LL; Yang, SY Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. Chem Biol Drug Des 89:585-598 (2017) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM223137
Synonyms:
P5i-6
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3O2
Mol. Mass.:
263.68
SMILES:
NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Structure:
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