Target
Caspase-4
Ligand
BDBM50233673
Substrate
n/a
Meas. Tech.
Caspase Catalytic Activity Assay
pH
7.4±n/a
IC50
5.7e+2± 7e+1 nM
Comments
extracted
Citation
 Smith, CESoti, SJones, TANakagawa, AXue, DYin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol 24:281-292 (2017) [PubMed]  Article 
Target
Name:
Caspase-4
Synonyms:
CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease
Type:
Enzyme
Mol. Mass.:
43257.75
Organism:
Homo sapiens (Human)
Description:
P49662
Residue:
377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
  
Inhibitor
Name:
BDBM50233673
Synonyms:
(+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-[4-(1-Oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-propionic acid | CHEMBL15870 | INDOPROFEN | cid_3718
Type:
Small organic molecule
Emp. Form.:
C17H15NO3
Mol. Mass.:
281.3059
SMILES:
CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: