Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM50233673
Substrate
n/a
Meas. Tech.
Caspase Catalytic Activity Assay
pH
7.4±n/a
IC50
3.0e+2± 1e+1 nM
Comments
extracted
Citation
 Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol 24:281-292 (2017) [PubMed]  Article 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM50233673
Synonyms:
(+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid | 2-[4-(1-Oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-propionic acid | CHEMBL15870 | INDOPROFEN | cid_3718
Type:
Small organic molecule
Emp. Form.:
C17H15NO3
Mol. Mass.:
281.3059
SMILES:
CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: