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Target
3-phosphoinositide-dependent protein kinase 1 [409-556]
Ligand
BDBM223487
Substrate
n/a
Meas. Tech.
Silico Screening Assay
Kd
2200±n/a nM
Citation
 Mahadevan, D; Meuillet, EJ; Mash, Jr., EA; Gokhale, VM; Powis, G; Zhang, S Small molecule inhibitors of the pleckstrin homology domain and methods for using same US Patent  US9320734 Publication Date 4/26/2016 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [409-556]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
Enzyme
Mol. Mass.:
17526.67
Organism:
Homo sapiens (Human)
Description:
PLECKSTRIN HOMOLOGY DOMAIN, RESIDUES 409-556 (PH domain)
Residue:
148
Sequence:
GSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
  
Inhibitor
Name:
BDBM223487
Synonyms:
US9320734, 333
Type:
Small organic molecule
Emp. Form.:
C21H18N8O4S
Mol. Mass.:
478.484
SMILES:
CC1=NN(C(=O)c2ccc(N)cc2)C(=O)C1\N=N\c1ccc(cc1)S(=O)(=O)Nc1ncccn1 |t:1|
Structure:
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