Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM224619
Substrate
n/a
Meas. Tech.
Binding Assay
pH
8±n/a
Ki
410±64 nM
Comments
extracted
Citation
 Göblyös, A; Brussee, J; Ijzerman, AP; Gao, Z; Jacobson, K A3 adenosine receptor allosteric modulators US Patent  US9326978 Publication Date 5/3/2016 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM224619
Synonyms:
US9326978, 32
Type:
Small organic molecule
Emp. Form.:
C22H22N4O
Mol. Mass.:
358.4363
SMILES:
COc1ccc(Nc2nc3ccccc3c3[nH]c(nc23)C2CCCC2)cc1
Structure:
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