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Target
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM224803
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
298.15±n/a K
IC50
388±n/a nM
Comments
extracted
Citation
 Heine, N; Eickmeier, C; Ferrera, M; Giovannini, R; Rosenbrock, H; Schaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent  US9328120 Publication Date 5/3/2016 
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM224803
Synonyms:
US9328120, 33 (enantiomer 1) | US9328120, 34 (enantiomer 2)
Type:
Small organic molecule
Emp. Form.:
C20H21F2N5O
Mol. Mass.:
385.4104
SMILES:
FC1(F)CCC(CC1)n1ncc2c1nc([nH]c2=O)C1CCC1c1ccccn1
Structure:
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