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Target
Dual specificity protein phosphatase 5 [180-384]
Ligand
BDBM50336799
Substrate
p-Nitrophenol (p-NPP)
Meas. Tech.
p-NPP Assay
Temperature
298.15±n/a K
Ki
25±5 nM
IC50
4.4e+4± 6e+3 nM
Comments
extracted
Citation
Neumann, TS; Span, EA; Kalous, KS; Bongard, R; Gastonguay, A; Lepley, MA; Kutty, RG; Nayak, J; Bohl, C; Lange, RG; Sarker, MI; Talipov, MR; Rathore, R; Ramchandran, R; Sem, DS Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. BMC Biochem 16:19 (2015) [PubMed] Article
More Info.:
Target
Name:
Dual specificity protein phosphatase 5 [180-384]
Synonyms:
DUS5_HUMAN | DUSP5 | Dual-specificity phosphatase 5 phophatase domain (DUSP5 PD) | VH3
Type:
Protein
Mol. Mass.:
22525.06
Organism:
Homo sapiens (Human)
Description:
Human DUSP5 C-terminal phosphatase domain (180-384 aa)
Residue:
205
Sequence:
VEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATSC
Inhibitor
Name:
BDBM50336799
Synonyms:
5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue | 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID | 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid(suramin) | 8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid | CHEMBL265502 | Germanin | Suramin hexasodium | US8835659, Suramin | Urea derivative | suramin
Type:
Small organic molecule
Emp. Form.:
C51H40N6O23S6
Mol. Mass.:
1297.28
SMILES:
Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O