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Target
Mitogen-activated protein kinase 1
Ligand
BDBM92119
Substrate
n/a
Meas. Tech.
Photometric_Method2
Ki
6±n/a nM
Citation
 D3R, DD Vertex ERK2 D3R 222:0 (2015) [PubMed] 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM92119
Synonyms:
erk000553
Type:
n/a
Emp. Form.:
C25H31N5O2
Mol. Mass.:
433.5459
SMILES:
CC1CCC(CC1)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1 |wD:23.25,(.19,-17.39,;1.09,-16.15,;2.62,-16.31,;3.53,-15.06,;2.9,-13.66,;1.37,-13.5,;.47,-14.74,;3.81,-12.41,;3.18,-11,;1.65,-10.84,;1.02,-9.44,;1.93,-8.19,;1.3,-6.78,;3.46,-8.35,;4.09,-9.76,;4.37,-7.1,;5.91,-7.1,;6.38,-5.64,;5.14,-4.73,;3.89,-5.64,;5.14,-3.19,;3.8,-2.42,;6.47,-2.42,;6.47,-.88,;5.14,-.11,;5.14,1.43,;7.8,-.11,;7.8,1.43,;9.14,2.2,;10.47,1.43,;10.47,-.11,;9.14,-.88,)|
Structure:
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