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Target
Bromodomain-containing protein 4 [44-166]
Ligand
BDBM50365262
Substrate
n/a
Meas. Tech.
TR-FRET Competition Assay
pH
7.5000±0.0000
Temperature
277.1500±0.0000 K
Kd
105.7±13.9 nM
Citation
 Jung, M; Philpott, M; Müller, S; Schulze, J; Badock, V; Eberspächer, U; Moosmayer, D; Bader, B; Schmees, N; Fernández-Montalván, A; Haendler, B Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem 289:9304-19 (2014) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-166]
Synonyms:
BRD4_HUMAN | BRD4 | HUNK1 | Bromodomain protein 4 bromodomain 1 (BRD4 BD1 WT)
Type:
Protein
Mol. Mass.:
14610.28
Organism:
Human
Description:
Human wild-type BRD4 BD1 (44-166 aa)
Residue:
123
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPT
  
Inhibitor
Name:
BDBM50365262
Synonyms:
CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 | US9695172, JQ1 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10925881, Name (S)-JQ1 | US10881668, Compound JQ1 | US11020380, Example JQ-1 | (+)-JQ1 | US11078188, Example (+)-JQ1 | US11466034, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1 | US20250084096, Compound A | US20250221977, Compound JQ1
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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