Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM228860
Substrate
n/a
Meas. Tech.
[3H]-NMS Binding Assay
IC50
14±n/a nM
Citation
 Fernandez Forner, MD; Prat Quinones, M; Buil Albero, MA Quinuclidine derivatives and medicinal compositions containing the same US Patent  US9333195 Publication Date 5/10/2016 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM228860
Synonyms:
US9333195, 114
Type:
Small Organic Molecule
Emp. Form.:
C31H32NO2
Mol. Mass.:
450.5907
SMILES:
CC1(C(=O)O[C@H]2C[N+]3(C\C=C\c4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12 |wU:5.4,TLB:4:5:17.18:20.21,(4.72,.22,;3.81,-1.03,;5.15,-1.8,;5.15,-3.34,;6.48,-1.03,;7.81,-1.8,;9.03,-1.01,;8.94,-2.55,;10.38,-2.01,;11.57,-2.99,;13.02,-2.45,;14.21,-3.42,;15.65,-2.88,;16.84,-3.86,;16.59,-5.38,;15.14,-5.92,;13.95,-4.94,;7.04,-3.02,;6.16,-3.86,;7.74,-3.31,;8.9,-4.47,;10.14,-3.76,;3.19,-2.44,;3.81,-3.84,;2.91,-5.09,;1.37,-4.93,;.75,-3.52,;1.65,-2.28,;1.33,-.77,;;,1.54,;1.33,2.31,;2.67,1.54,;2.67,,)|
Structure:
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