Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM230658
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
9±n/a nM
Comments
extracted
Citation
 Blaskovich, MA; Cassidy, PJ Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor US Patent  US9340517 Publication Date 5/17/2016 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
  
Inhibitor
Name:
BDBM230658
Synonyms:
US9340517, 33
Type:
Small organic molecule
Emp. Form.:
C36H43ClN4O2
Mol. Mass.:
599.205
SMILES:
Clc1ccc(\C=C\C(=O)NC[C@H]2CCN(CC(c3ccccc3)c3ccccc3)C(=O)[C@@H](CCN3CCCCC3)N2)cc1
Structure:
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