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Target
Tyrosine-protein phosphatase non-receptor type 9 [277-582]
Ligand
BDBM231165
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
pH
7±n/a
IC50
900±20 nM
Comments
extracted
Citation
 Zhang, Z; Zhang, S Inhibitors of protein tyrosine phosphatases US Patent  US9340574 Publication Date 5/17/2016 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9 [277-582]
Synonyms:
PTN9_HUMAN | PTPN9 | Tyrosine-protein phosphatase non-receptor type 9 (PTP-MEG2)
Type:
Protein
Mol. Mass.:
35160.61
Organism:
Homo sapiens (Human)
Description:
residues 277-582
Residue:
306
Sequence:
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVS
  
Inhibitor
Name:
BDBM231165
Synonyms:
US9340574, 3
Type:
Small organic molecule
Emp. Form.:
C24H28F2IN4O7P
Mol. Mass.:
680.3768
SMILES:
CC(=O)NC(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)C(=O)NC(CCCNC(=O)c1cccc(I)c1)C(N)=O
Structure:
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