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Target
Secreted cathepsin L 1
Ligand
BDBM232227
Substrate
n/a
Meas. Tech.
Cathepsin L Enzyme Assay
IC50
5.5e+3±n/a nM
Citation
 Moran, BW; Anderson, FP; Ruth, DM; Fágáin, CO; Dalton, JP; Kenny, PT Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1. J Enzyme Inhib Med Chem 25:1-12 (2010) [PubMed]  Article 
Target
Name:
Secreted cathepsin L 1
Synonyms:
Cathepsin L1 (CL1) | Cysteine cathepsin L endoprotease
Type:
Protein
Mol. Mass.:
36773.95
Organism:
Fasciola hepatica (Liver fluke)
Description:
n/a
Residue:
326
Sequence:
MRLFVLAVLTVGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSRPWGNNGCGGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGFYTVHSGSEVELKNLVGAEGPAAVAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGLSWGERGYIRMVRNRGNMCGIASLASLPMVARFP
  
Inhibitor
Name:
BDBM232227
Synonyms:
N-2,4-difluorobenzoyl-L-leucine-glycine nitrile (23)
Type:
Small organic molecule
Emp. Form.:
C15H17F2N3O2
Mol. Mass.:
309.3112
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(F)cc1F)C(=O)NCC#N |r|
Structure:
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