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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM232943
Substrate
n/a
Meas. Tech.
V79-Human-CYP11B2 and V79-Human-CYP11B1 Assays
Temperature
310.15±n/a K
IC50
11.7±n/a nM
Comments
extracted
Citation
 Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; London, C; MacLean, J; Park, MK; Ratcliffe, P; Xiong, Y; Samanta, SK; Kulkarni, BA Pyrazolopyridyl compounds as aldosterone synthase inhibitors US Patent  US9351973 Publication Date 5/31/2016 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM232943
Synonyms:
US9351973, 13 | US9844553, 13
Type:
Small organic molecule
Emp. Form.:
C13H13FN4O
Mol. Mass.:
260.2669
SMILES:
CCc1c2NC(=O)CCn2nc1-c1cncc(F)c1
Structure:
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