Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM292054
Substrate
n/a
Meas. Tech.
Biological Assays Calcium Flux Assay
pH
7.4±n/a
IC50
0.050±n/a nM
Comments
extracted
Citation
Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent US10100045 Publication Date 10/16/2018 More Info.:
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
Inhibitor
Name:
BDBM292054
Synonyms:
5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-7- | US10100045, Example 25
Type:
Small organic molecule
Emp. Form.:
C20H17F3N4O
Mol. Mass.:
386.3704
SMILES:
Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1
Structure:
