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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM233174
Substrate
n/a
Meas. Tech.
Pharmacological In Vitro Assay
pH
8.2±n/a
Temperature
277.15±n/a K
Ki
>10000±0.0 nM
Comments
extracted
Citation
 Liutkus, M; Caijo, F; Girard, AL; Ayral, E; Audinot, V; Boutin, JA; Renard, P; Caignard, DH; Dacquet, C; Ktorza, A; Mosset, P; Grée, R Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors. J Enzyme Inhib Med Chem 25:653-72 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM233174
Synonyms:
8-Hydroxy-8-[2-(4,4,4-trifluoro-butoxy)-quinolin-3-yl]-oct-5-ynoic acid methyl ester (8e)
Type:
Small organic molecule
Emp. Form.:
C22H24F3NO4
Mol. Mass.:
423.4255
SMILES:
COC(=O)CCCC#CCC(O)c1cc2ccccc2nc1OCCCC(F)(F)F
Structure:
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