Reaction Details
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Prolyl endopeptidase FAP
Ligand
BDBM50434171
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
8.3±n/a
Temperature
310.15±n/a K
IC50
160±10 nM
Comments
extracted
Citation
Jansen, K; De Meester, I; Heirbaut, L; Cheng, JD; Joossens, J; Augustyns, K; Van Der Veken, P FAP inhibitors US Patent US9346814 Publication Date 5/24/2016 More Info.:
Target
Name:
Prolyl endopeptidase FAP
Synonyms:
Fap | Fibroblast activation protein (FAP) | SEPR_MOUSE | Seprase
Type:
Enzyme
Mol. Mass.:
87949.14
Organism:
Mus musculus (Mouse)
Description:
P97321
Residue:
761
Sequence:
MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD
Inhibitor
Name:
BDBM50434171
Synonyms:
CHEMBL2385298 | US9346814, Cmpd No 38 Example 43
Type:
Small organic molecule
Emp. Form.:
C17H16N4O3
Mol. Mass.:
324.3339
SMILES:
Oc1cnc2ccccc2c1C(=O)NCC(=O)N1CCC[C@H]1C#N |r|
Structure:
