Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [645-1186]
Ligand
BDBM49214
Substrate
n/a
Meas. Tech.
EGFR Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
25740±n/a nM
Comments
extracted
Citation
 Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem 26:37-45 (2011) [PubMed]  Article 
Target
Name:
Epidermal growth factor receptor [645-1186]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1
Type:
Protein
Mol. Mass.:
60974.10
Organism:
Homo sapiens (Human)
Description:
Human EGFR cytoplasmic domain (645-1186 aa)
Residue:
542
Sequence:
SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGI
  
Inhibitor
Name:
BDBM49214
Synonyms:
2-Hydroxy-N-p-tolylbenzamide (10) | 2-hydroxy-N-(4-methylphenyl)benzamide | 2-hydroxy-N-(p-tolyl)benzamide | MLS000053968 | N-(4-methylphenyl)-2-oxidanyl-benzamide | SMR000061984 | cid_478805
Type:
Small organic molecule
Emp. Form.:
C14H13NO2
Mol. Mass.:
227.2585
SMILES:
Cc1ccc(NC(=O)c2ccccc2O)cc1
Structure:
Search PDB for entries with ligand similarity: