Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [645-1186]
Ligand
BDBM234315
Substrate
n/a
Meas. Tech.
EGFR Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
50000±n/a nM
Comments
extracted
Citation
 Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem 26:37-45 (2011) [PubMed]  Article 
Target
Name:
Epidermal growth factor receptor [645-1186]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1
Type:
Protein
Mol. Mass.:
60974.10
Organism:
Homo sapiens (Human)
Description:
Human EGFR cytoplasmic domain (645-1186 aa)
Residue:
542
Sequence:
SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGI
  
Inhibitor
Name:
BDBM234315
Synonyms:
N-(2,4-difluorophenyl)-2-hydroxy-4-methylbenzamide (17)
Type:
Small organic molecule
Emp. Form.:
C14H11F2NO2
Mol. Mass.:
263.2394
SMILES:
Cc1ccc(C(=O)Nc2ccc(F)cc2F)c(O)c1
Structure:
Search PDB for entries with ligand similarity: