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Target
UDP-glucuronosyltransferase 2B10
Ligand
BDBM21361
Substrate
Diclofenac
Meas. Tech.
UDP-glucuronosyltransferase Activity Assay
IC50
>3.00e+5±n/a nM
Citation
 Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem 26:386-93 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 2B10
Synonyms:
UDB10_HUMAN | UGT2B10 | Uridine-5'-diphosphoglucuronosyltransferase 2B10
Type:
Enzyme
Mol. Mass.:
60792.40
Organism:
Homo sapiens (Human)
Description:
P36537
Residue:
528
Sequence:
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD
  
Inhibitor
Name:
BDBM21361
Synonyms:
(5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione | (5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione | Mephenytoin, D- | S-Mephenytoin | S-mephentoin
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
CC[C@]1(NC(=O)N(C)C1=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13066
Synonyms:
2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid | CHEMBL139 | Diclofenac | US11337935, Compound Diclofenac | US11478464, Compound Diclofenac | US11786535, Compound Diclofenac | {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2NO2
Mol. Mass.:
296.149
SMILES:
OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: