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Target
Glucagon receptor
Ligand
BDBM235137
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.2±n/a nM
Comments
extracted
Citation
 Lin, S; Zhang, F; Parmee, ER; Dewnani, SV Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use US Patent  US9359339 Publication Date 6/7/2016 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM235137
Synonyms:
US9359339, 27
Type:
Small organic molecule
Emp. Form.:
C30H23Cl2F3N2O3S
Mol. Mass.:
619.481
SMILES:
OC(=O)CCNC(=O)c1ccc(cc1)[C@@H](CCC(F)(F)F)C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(Cl)cc1
Structure:
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