Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [668-1210,T790M,L858R]
Ligand
BDBM50123163
Substrate
n/a
Meas. Tech.
Luminescence Kinase Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
22±0.0 nM
Comments
extracted
Citation
 Zhang, D Quinazoline derivatives as kinases inhibitors and methods of use thereof US Patent  US9388160 Publication Date 7/12/2016 
Target
Name:
Epidermal growth factor receptor [668-1210,T790M,L858R]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(T790M/L858R) | HER1
Type:
Enzyme
Mol. Mass.:
61378.18
Organism:
Homo sapiens (Human)
Description:
a.a: 668-1210
Residue:
543
Sequence:
MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM50123163
Synonyms:
CHEMBL3622672 | US9388160, 12
Type:
Small organic molecule
Emp. Form.:
C26H27N5O2
Mol. Mass.:
441.5249
SMILES:
COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1NC(=O)\C=C\CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: