Reaction Details
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Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)
Ligand
BDBM135818
Substrate
n/a
Meas. Tech.
TR-FRET-Based Assay
Temperature
303.15±n/a K
IC50
151±n/a nM
Comments
extracted
Citation
Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 More Info.:
Target
Name:
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) | phosphodiesterase 4D
Type:
Enzyme
Mol. Mass.:
68570.22
Organism:
Homo sapiens (Human)
Description:
Q08499-3
Residue:
604
Sequence:
MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
Inhibitor
Name:
BDBM135818
Synonyms:
US10085990, Example 92 | US10568888, Example 92 | US8853226, 92 | US9393245, 92 | US9833457, 92
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4O5S
Mol. Mass.:
514.981
SMILES:
COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Structure:
