Reaction Details Report a problem with these data
Target
Carbonic anhydrase 3
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
CA Activity Assay
pH
7.5000±n/a
Ki
510±0.0 nM
Comments
500 mM acetaldehyde extracted
Citation
 Bootorabi, F; Jänis, J; Hytönen, VP; Valjakka, J; Kuuslahti, M; Vullo, D; Niemelä, O; Supuran, CT; Parkkila, S Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases. J Enzyme Inhib Med Chem 26:862-70 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 3
Synonyms:
Carbonic anhydrase 3 (CA III) | CA-III | Carbonate dehydratase III | Carbonic anhydrase III (CA III) | CAH3_HUMAN | CA3 | Carbonic anhydrase | Carbonic Anhydrase III
Type:
Enzyme
Mol. Mass.:
29562.11
Organism:
Human
Description:
Human cloned isozyme.
Residue:
260
Sequence:
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
  
Inhibitor
Name:
BDBM10880
Synonyms:
Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolamide | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Acetazolamide, AZA | AZA | Acetazolamide, 5 | Sulfonamide, 1 | Acerazolamide, AAZ | Acetazolamide, AZM | sulfonamide 1 | Acetazolamide (AAZ) | Acetazolamide (AZM) | AZM acetazolamide | Acetazolamide (AZA) | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | US12527778, Example acetazolamide
Type:
Small organic molecule
Emp. Form.:
C4H6N4O3S2
Mol. Mass.:
221.99
SMILES:
CC(=O)Nc1nnc(s1)S(=O)(=O)N
Structure:
Search PDB for entries with ligand similarity: