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Target
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Ligand
BDBM235755
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.5±n/a
IC50
58±n/a nM
Comments
extracted
Citation
 Wu, F; Wang, A Bicyclic substituted pyrimidine compounds US Patent  US9359371 Publication Date 6/7/2016 
Target
Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Synonyms:
PDE6A | PDE6A_BOVIN | PDEA | Phosphodiesterase 6 | Phosphodiesterase 6A
Type:
Enzyme
Mol. Mass.:
99320.22
Organism:
Bos taurus (Bovine)
Description:
P11541
Residue:
859
Sequence:
MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYHVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYETKMKGLEEEKQKQQAANQAAAGSQHGGKQPGGGPASKSCCVQ
  
Inhibitor
Name:
BDBM235755
Synonyms:
US9359371, 38
Type:
Small organic molecule
Emp. Form.:
C25H32ClN5O3
Mol. Mass.:
486.006
SMILES:
COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.88,;-8.05,-4.65,;-6.72,-3.88,;-5.33,-4.62,;-4,-3.85,;-4,-2.31,;-2.67,-1.54,;-1.33,-2.31,;,-1.54,;,-0,;1.33,.77,;2.67,-0,;2.67,-1.54,;1.33,-2.31,;1.33,-3.85,;,-4.62,;2.67,-4.62,;4,-3.85,;4,-2.31,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;6.67,-3.85,;5.33,-4.62,;1.33,2.31,;.09,3.21,;.56,4.68,;2.1,4.68,;3.59,5.07,;2.5,6.16,;2.58,3.21,;-5.33,-1.54,;-6.67,-2.31,;-8,-1.54,)|
Structure:
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