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Target
Suppressor of tumorigenicity 14 protein [596-855]
Ligand
BDBM236493
Substrate
n/a
Meas. Tech.
Inhibition Enzymatic Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
0.088±0.01 nM
Comments
extracted
Citation
 Richter, M; Leduc, R; Colombo, E; Marsault, E Matriptase inhibitors and uses thereof against orthomyxoviridae infections US Patent  US9365853 Publication Date 6/14/2016 
Target
Name:
Suppressor of tumorigenicity 14 protein [596-855]
Synonyms:
Matriptase | PRSS14 | SNC19 | ST14 | ST14_HUMAN | TADG15
Type:
Enzyme
Mol. Mass.:
28561.29
Organism:
Homo sapiens (Human)
Description:
amino acids 596-855
Residue:
260
Sequence:
GSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
  
Inhibitor
Name:
BDBM236493
Synonyms:
US10988505, Comparative #2 | US9365853, 4
Type:
Small organic molecule
Emp. Form.:
C21H30N8O4S
Mol. Mass.:
490.579
SMILES:
C[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
Structure:
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