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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM236525
Substrate
n/a
Meas. Tech.
Radioligand-Binding Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
28.3±0.0 nM
Citation
 Nirogi, RV; Kambhampati, R; Kothmirkar, P; Konda, J; Bandyala, TR; Gudla, P; Arepalli, S; Gangadasari, NP; Shinde, AK; Deshpande, AD; Dwarampudi, A; Chindhe, AK; Dubey, PK Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands. J Enzyme Inhib Med Chem 27:443-50 (2012) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM236525
Synonyms:
2-Methoxy-10-[(2-N,N-dimethylamino-2-ethyl)ethyl]benzo[d]isothiazolo[3,2-a]indol-S,S-dioxide (16)
Type:
Small organic molecule
Emp. Form.:
C22H25NO3S
Mol. Mass.:
383.504
SMILES:
CCC(CC1=C2C(c3ccc(OC)cc13)S(=O)(=O)c1ccccc21)N(C)C |t:4|
Structure:
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