Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM237106
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
21±n/a nM
Comments
extracted
Citation
 Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Randl, SA; Rogel, O; Vulpetti, A Pyrrolidine derivatives and their use as complement pathway modulators US Patent  US9388199 Publication Date 7/12/2016 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM237106
Synonyms:
US9388199, 15
Type:
Small organic molecule
Emp. Form.:
C25H25F3N6O5
Mol. Mass.:
546.4984
SMILES:
CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCCOC(F)(F)F)c2ccc(OCc3ncccn3)cc12 |r|
Structure:
Search PDB for entries with ligand similarity: