Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [1-473]
Ligand
BDBM237509
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
IC50
24±n/a nM
Comments
extracted
Citation
 Ren, B; Zhou, C; Wang, H Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones US Patent  US9393232 Publication Date 7/19/2016 
Target
Name:
Bromodomain-containing protein 2 [1-473]
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3
Type:
Enzyme
Mol. Mass.:
52271.20
Organism:
Homo sapiens (Human)
Description:
aa 1-473
Residue:
473
Sequence:
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGL
  
Inhibitor
Name:
BDBM237509
Synonyms:
US9393232, 2.10a | US9393232, 2.10b
Type:
Small organic molecule
Emp. Form.:
C22H23N3O3
Mol. Mass.:
377.4363
SMILES:
C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: