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Target
E3 ubiquitin-protein ligase SMURF1 [420-757]
Ligand
BDBM238966
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
440±n/a nM
Comments
extracted
Citation
 Edwards, A; Ahmed, M; Pulz, RA; Rooney, LA; Smith, N; Troxler, TJ Carboxamide derivatives US Patent  US9403833 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:
HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:
Enzyme
Mol. Mass.:
39188.96
Organism:
Homo sapiens (Human)
Description:
HECTdomain amino acid 420-757
Residue:
338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
  
Inhibitor
Name:
BDBM238966
Synonyms:
US9403833, 1
Type:
Small organic molecule
Emp. Form.:
C22H27ClN6O3
Mol. Mass.:
458.941
SMILES:
COc1ccc(c(Cl)c1)-n1nnc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C
Structure:
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