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Target
E3 ubiquitin-protein ligase SMURF1 [420-757]
Ligand
BDBM238975
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
92±n/a nM
Comments
extracted
Citation
 Edwards, A; Ahmed, M; Pulz, RA; Rooney, LA; Smith, N; Troxler, TJ Carboxamide derivatives US Patent  US9403833 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:
HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:
Enzyme
Mol. Mass.:
39188.96
Organism:
Homo sapiens (Human)
Description:
HECTdomain amino acid 420-757
Residue:
338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
  
Inhibitor
Name:
BDBM238975
Synonyms:
US9403833, 10 | US9403833, 12
Type:
Small organic molecule
Emp. Form.:
C24H29ClN6O2
Mol. Mass.:
468.979
SMILES:
Cc1c(NC(=O)c2nnn(c2C)-c2ccc(cc2Cl)C2CC2)c(=O)n(C2CCCCC2)n1C
Structure:
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