Reaction Details Report a problem with these data
Target
Siderophore-binding protein
Ligand
BDBM11622
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
pH
8.3±0
Temperature
298.15±0 K
Ki
1.7e+2±n/a nM
Citation
 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ß-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem 28:384-7 (2013) [PubMed]  Article 
Target
Name:
Siderophore-binding protein
Synonyms:
β-Carbonic anhydrase 3 (CA 3)
Type:
Enzyme
Mol. Mass.:
17663.22
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
174
Sequence:
MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRGDYAPVVVREGANVQDGAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVLDGAVIGARCMIAAGALVVAGTQIPAGMLVTGAPAKVKGPIEGTGAEMWVNVNPQAYRDLAARHLAGLEPM
  
Inhibitor
Name:
BDBM11622
Synonyms:
β-CA inhibitor, 1 | 2-N-(4-amino-3-chlorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide | 5-(4-Amino-3-chlorobenzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide | aminobenzolamide 17c
Type:
Small organic molecule
Emp. Form.:
C8H8ClN5O4S3
Mol. Mass.:
369.828
SMILES:
Nc1ccc(cc1Cl)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O
Structure:
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