Reaction Details Report a problem with these data
Target
Siderophore-binding protein
Ligand
BDBM10886
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
pH
8.3±0
Temperature
298.15±0 K
Ki
3.4e+2±n/a nM
Citation
 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ß-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem 28:384-7 (2013) [PubMed]  Article 
Target
Name:
Siderophore-binding protein
Synonyms:
β-Carbonic anhydrase 3 (CA 3)
Type:
Enzyme
Mol. Mass.:
17663.22
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
174
Sequence:
MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRGDYAPVVVREGANVQDGAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVLDGAVIGARCMIAAGALVVAGTQIPAGMLVTGAPAKVKGPIEGTGAEMWVNVNPQAYRDLAARHLAGLEPM
  
Inhibitor
Name:
BDBM10886
Synonyms:
2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | BZA1 | Benzolamide | Benzolamide (BZA) | CHEMBL73962
Type:
Small organic molecule
Emp. Form.:
C8H8N4O4S3
Mol. Mass.:
320.369
SMILES:
NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
Structure:
Search PDB for entries with ligand similarity: