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Target
Nociceptin receptor
Ligand
BDBM239890
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
1.55±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239890
Synonyms:
US9403767, 48 | US9403767, 49
Type:
Small organic molecule
Emp. Form.:
C25H36N2
Mol. Mass.:
364.5667
SMILES:
CCCCN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1 |(8,-1.35,;6.66,-2.12,;5.33,-1.35,;3.99,-2.12,;2.66,-1.35,;3.57,-.11,;1.33,-2.12,;-.21,-2.07,;-1.03,-3.38,;-.31,-4.74,;1.23,-4.79,;2.05,-3.48,;-.41,-6.27,;.86,-7.13,;-1.14,-7.63,;-1.64,-5.51,;-1.64,-7.05,;-2.97,-7.82,;-4.31,-7.05,;-4.31,-5.51,;-2.97,-4.74,;1.43,-.59,;.16,.27,;.27,1.81,;1.65,2.48,;2.93,1.62,;2.82,.09,)|
Structure:
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