Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM239938
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
176.67±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239938
Synonyms:
US9403767, 122
Type:
Small organic molecule
Emp. Form.:
C24H33N3O
Mol. Mass.:
379.5383
SMILES:
CNC(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1 |(-6.72,-6.08,;-5.38,-5.31,;-4.05,-6.08,;-4.05,-7.62,;-2.72,-5.31,;-1.38,-6.08,;-2.29,-7.32,;-.05,-5.31,;-.77,-3.95,;.04,-2.64,;1.58,-2.69,;2.31,-4.05,;1.49,-5.36,;2.92,-1.92,;4.25,-2.69,;3.82,-.68,;1.69,-1.16,;.41,-.3,;.52,1.24,;1.91,1.91,;3.18,1.05,;3.07,-.48,;-.16,-6.84,;1.12,-7.7,;1.01,-9.24,;-.37,-9.92,;-1.65,-9.05,;-1.54,-7.52,)|
Structure:
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