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Target
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Ligand
BDBM152706
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±0
Temperature
298.15±0 K
Ki
1.0e+2±n/a nM
Citation
 Cervelli, M; Polticelli, F; Fiorucci, L; Angelucci, E; Federico, R; Mariottini, P Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine. J Enzyme Inhib Med Chem 28:463-7 (2013) [PubMed]  Article 
Target
Name:
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Synonyms:
Acetylpolyamine oxidase (APAO) | PAO | PAOX | PAOX_HUMAN | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Polyamine oxidase
Type:
Enzyme
Mol. Mass.:
70274.33
Organism:
Homo sapiens (Human)
Description:
Q6QHF9
Residue:
511
Sequence:
MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDTVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAWFRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYSTTHGALLSGWREADRLLSLWAPQVQQPRPRL
  
Inhibitor
Name:
BDBM152706
Synonyms:
Chlorhexidine | Chlorhexidine (1)
Type:
Small organic molecule
Emp. Form.:
C22H30Cl2N10
Mol. Mass.:
505.447
SMILES:
Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
Structure:
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