Reaction Details Report a problem with these data
Target
Genome polyprotein [2420-3010]
Ligand
BDBM240847
Substrate
n/a
Meas. Tech.
HCV Replicon Assay
pH
7.5±n/a
Temperature
300.15±n/a K
EC50
>20000±n/a nM
Comments
extracted
Citation
 Du, J; Sofia, MJ 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections US Patent  US9394331 Publication Date 7/19/2016 
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65783.36
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM240847
Synonyms:
US9394331, 72
Type:
Small organic molecule
Emp. Form.:
C14H19N5O5
Mol. Mass.:
337.3312
SMILES:
COc1nc(N)nc2n(cnc12)C1OC(CO)[C@@H](O)[C@]11CCCO1 |r|
Structure:
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