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Target
Genome polyprotein [1973-2420]
Ligand
BDBM241857
Substrate
n/a
Meas. Tech.
Luciferase Assay
EC50
10.552±n/a nM
Citation
 Zhang, J; Zhang, Y; Xie, H; Ren, Q; Hu, B; Fu, C; Wu, X; Li, S; Wang, C; Zhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent  US9416139 Publication Date 8/16/2016 
Target
Name:
Genome polyprotein [1973-2420]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCV1
Type:
Enzyme
Mol. Mass.:
48946.19
Organism:
Hepatitis C virus genotype 1a (HCV)
Description:
aa 1973-2420
Residue:
448
Sequence:
SGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYKGVWRVDGIMHTRCHCGAEITGHVKNGTMRIVGPRTCRNMWSGTFPINAYTTGPCTPLPAPNYTFALWRVSAEEYVEIRQVGDFHYVTGMTTDNLKCPCQVPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLHEYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSVASSSASQLSAPSLKATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREISVPAEILRKSRRFAQALPVWARPDYNPPLVETWKKPDYEPPVVHGCPLPPPKSPPVPPPRKKRTVVLTESTLSTALAELATRSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDAESYSSMPPLEGEPGDPDLSDGSWSTVSSEANAEDVVCC
  
Inhibitor
Name:
BDBM241857
Synonyms:
US9416139, 35
Type:
Small organic molecule
Emp. Form.:
C53H63N7O7
Mol. Mass.:
910.11
SMILES:
COC(=O)NC(C(C)C)C(=O)N1CCCC1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2[nH]c(cc(=O)c2c1)C1CCCN1C(=O)C(NC(=O)OC)C(C)C
Structure:
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