Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM46100
Substrate
n/a
Meas. Tech.
Cellular Uptake Assay
IC50
1200±n/a nM
Citation
 Warrell, Jr., RP Methods for reducing uric acid levels using barbiturate derivatives US Patent  US9428466 Publication Date 8/30/2016 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM46100
Synonyms:
6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carboxamide | 6-hydroxy-2,4-dioxo-N-phenyl-1H-pyrimidine-5-carboxamide | 6-oxidanyl-2,4-bis(oxidanylidene)-N-phenyl-1H-pyrimidine-5-carboxamide | UPDDI-00294852 | US9428466, 2-oxo-desthiomerbarone | cid_100782
Type:
Small organic molecule
Emp. Form.:
C11H9N3O4
Mol. Mass.:
247.2069
SMILES:
Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1
Structure:
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