Reaction Details Report a problem with these data
Target
Interstitial collagenase [100-268]
Ligand
BDBM7459
Substrate
n/a
Meas. Tech.
cd-MMP-1 Activity Assay
pH
7.5±n/a
IC50
3.03e+3±n/a nM
Comments
extracted
Citation
 Lu, W; Zhu, J; Zou, S; Li, X; Huang, J The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem 28:741-6 (2013) [PubMed]  Article 
Target
Name:
Interstitial collagenase [100-268]
Synonyms:
CLG | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 (cd-MMP-1)
Type:
Enzyme
Mol. Mass.:
18886.85
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human MMP-1 (100-268 aa)
Residue:
169
Sequence:
FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQ
  
Inhibitor
Name:
BDBM7459
Synonyms:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one | CHEMBL151 | Luteolin (27) | Luteolin (4) | acs.jmedchem.1c00409_ST.600 | cid_5280445 | luteolin | med.21724, Compound 3
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: