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Target
Genome polyprotein [1973-2419]
Ligand
BDBM244108
Substrate
n/a
Meas. Tech.
Immumoenzymatic Assay
Temperature
310.15±n/a K
IC50
0.0046±n/a nM
Comments
extracted
Citation
 Ivachtchenko, AV; Bichko, VV; Mitkin, OD Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof US Patent  US9428491 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [1973-2419]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48705.67
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q9WMX2[1973-2419]
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM244108
Synonyms:
US9428491, 1.6: 2HCl
Type:
Small organic molecule
Emp. Form.:
C42H48N8O6
Mol. Mass.:
760.8805
SMILES:
COC(=O)N[C@H](C(C)C)C(=O)N1CCC[C@@H]1c1ncc([nH]1)C#CC#Cc1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C |r|
Structure:
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