Reaction Details
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Ligand
BDBM50434363
Substrate
n/a
Meas. Tech.
HotSpot Technology Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
9.64±n/a nM
Comments
extracted
Citation
Leblond, B; Casagrande, A; Desire, L; Foucourt, A; Besson, T DYRK1 inhibitors and uses thereof US Patent US9446044 Publication Date 9/20/2016 More Info.:
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Synonyms:
DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK
Type:
Enzyme
Mol. Mass.:
69222.24
Organism:
Homo sapiens (Human)
Description:
Q9Y463
Residue:
629
Sequence:
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
Inhibitor
Name:
BDBM50434363
Synonyms:
CHEMBL2386765 | US9446044, 66
Type:
Small organic molecule
Emp. Form.:
C17H12FN5OS
Mol. Mass.:
353.373
SMILES:
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1
Structure:
