Reaction Details Report a problem with these data
Target
Pancreatic triacylglycerol lipase
Ligand
BDBM24567
Substrate
BDBM246504
Meas. Tech.
In Vitro Pancreatic Lipase Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
2.6e+2± 1e+1 nM
IC50
1.24e+3± 5e+1 nM
Citation
 Yang, MH; Chin, YW; Yoon, KD; Kim, J Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita). J Enzyme Inhib Med Chem 29:1-6 (2014) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_PIG | PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase
Type:
Enzyme
Mol. Mass.:
50080.69
Organism:
Sus scrofa (Pig)
Description:
P00591
Residue:
450
Sequence:
SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
  
Inhibitor
Name:
BDBM24567
Synonyms:
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical
Type:
Small organic molecule
Emp. Form.:
C29H53NO5
Mol. Mass.:
495.7348
SMILES:
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM246504
Synonyms:
4-Methylumbelliferyl oleate (4-MU oleate)
Type:
Small organic molecule
Emp. Form.:
C28H40O4
Mol. Mass.:
440.6148
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)Oc1ccc2c(C)cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: