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Target
Carbonic anhydrase 2
Ligand
BDBM246507
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
1.4211e+5±n/a nM
Citation
 Celik, F; Arslan, M; Yavuz, E; Demir, D; Gençer, N Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas. J Enzyme Inhib Med Chem 29:18-22 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM246507
Synonyms:
1-(4-Fluorophenyl)-3-(4-(1,3,7,7-tetramethyl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)urea (4c)
Type:
Small organic molecule
Emp. Form.:
C25H27FN4O3
Mol. Mass.:
450.5053
SMILES:
CN1C(C2=C(CC(C)(C)CC2=O)N(C)C1=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1 |t:3|
Structure:
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